UI responsiveness: OSX vs. Windows, iOS vs. Android
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Ruby/Rails developer and designer in London.
Here are articles that I've read and found interesting, mostly from places like Hacker News and a collection of RSS feeds that I follow. It's mainly here for my own records but you're welcome to follow me.
I'm starring items I find in Google Reader (using Byline) and using ifttt to publish them to Tumblr. This way I can read and reblog articles on the tube (London underground) where there is no Internet connection.
You can also subscribe via email if you like
N.B I'm investigating why the full contents of the post are sometimes posted. They are intended to be links but sometimes the whole post comes through. Also I'd like a way to add a note to the post but since Google removed most of the useful features in reader, I'm not sure how I can do this.
— @samoli on Twitter.
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Note: This post originally appeared in TechCrunch
Here’s the gist:
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What happens when you take a monster 4.1 meter telescope in the southern hemisphere and point it at the same patch of sky for 55 hours?
This. Oh my, this:
[Click to embiggen.]
OK, I know. At first glance it doesn’t look like much, does it? Just a field of stars. However, here’s the important bit: I had to take the somewhat larger original image and reduce it in size to fit my 610-pixel-wide blog. So how much bigger is the original?
It’s 17,000 x 11,000 pixels! If you happen to be sitting on a T1 line, then you can grab this massive 250 Mb file. And I surely suggest you do.
Because yeah, the brightest objects you see in this are stars. Probably a few hundred of them. But you have to look at the bigger image ! Why? Because what’s amazing, truly jaw-dropping and incredible is this:
There are over 200,000 galaxies filling this image!
Ye. Gads.
Here’s a zoom of the image, centered on what looked to me to be one of the biggest galaxies in the frame, a nice edge-on spiral.
With the exception of a handful of blue-looking stars, everything in this zoom is a galaxy, probably billions of light years away. Those tiny red dots are galaxies so far away they crush our minds to dust: we’re seeing them with light that left them shortly after the Universe itself formed.
This light is ancient. And it came a long, long way.
By the way, that picture of the spiral there is not even at full resolution! Just to give you an idea, I cropped out just that galaxy in the full-res image and inset it here. If you want to find it in the full frame, it’s about one-third of the way in from the left, and one-third of the way down from the top. Happy hunting.
[Edited to add: I forgot to add that this galaxy is warped! See how the disk flares up on the left and down on the right, just a bit? This is very common in disk galaxies, and our own Milky Way does it too (see #9 at that link). It’s usually caused when a nearby galaxy’s gravity torques on the stars in the disk.]
These images were taken with VISTA, the European Southern Observatory’s Visible and Infrared Survey Telescope for Astronomy (VISTA), a 4.1 meter telescope in Chile. This huge image is actually composed of 6000 separate images, and is the single deepest infrared picture of the sky ever taken with this field of view. Hubble can get deeper, for example, but sees a much, much smaller part of the sky.
By looking in the infrared we can see farther into space. Because space is expanding, light from distant galaxies gets red-shifted (like the Doppler effect on a cosmic scale). Young galaxies are generally furiously forming stars, and that makes them blast out ultraviolet light. But a young galaxy seen from very far away has that UV light red shifted into the infrared. So to us, billions of light years distant, we see it pouring out IR light. Looking there means we can see these extraordinarily remote galaxies more easily. If you scan the full-size image, you’ll see lots of tiny, very red dots. Those are most likely the most distant objects in this picture, appearing redshifted, dimmed, and shrunken due to their terrible distance.
Also, looking in the infrared makes stars that look red to our eyes appear blue in the image! Most of the stars in this image are weak, cool, dim red dwarfs. They look blue because this image is false color. It uses three filters to isolate different colors of infrared: 1.3 microns, 1.7 microns, and 2.2 microns (colored blue, green, and red in this image, respectively). The reddest light the human eye can typically see is about 0.7 microns, so these are well outside human range. Many red dwarfs put out light at 1.3 microns, but not nearly as much at 1.7 and 2.2. Since the 1.3 micron light is colored blue in the image, that makes the stars look blue, even though to you they’d look red!
And what a view! Here’s another interesting bit I happened to stumble on while just scanning this monster image:
Isn’t that interesting? There’s a long jet of material apparently coming from that bloated galaxy on the left (I increased the brightness and contrast of this picture to make it more obvious; it was subtle in the original image but I have a lot of practice picking out things like this). Big galaxies have supermassive black holes in their cores, and these sometimes accelerate huge beams of matter and energy that blast out. But wait! The stream goes right through that smaller galaxy on the right. Is that a coincidence — the jet is coming from the big one and happens to pass in front of a more distant galaxy? Or is that smaller one the source of the jet, and actually has two jets coming out of either side? That’s actually a more common occurrence. Beats me. I could argue either way. We’d need spectra of the galaxies to know for sure.
And funny: I went back to the original image to see where I cut that galaxy out, and now I can’t find it. Holy crap. I mean, seriously, I couldn’t find it. That’s how big this image is.
Of course, you can find a dozen galaxies just like it. I also found several gorgeous spirals (look all the way on the left; one is cut off on the edge of the frame and it’s really something). Some were edge-on like the one above, others face-on. There are countless blobby ones, and even more that are just dots, so far away we see them as dimensionless points.
I’ve spent years studying all this, and it still sometimes gets to me: just how flipping BIG the Universe is! And this picture is still just a tiny piece of it: it’s 1.2 x 1.5 degrees in size, which means it’s only 0.004% of the sky! And it’s not even complete: more observations of this region are planned, allowing astronomers to see even deeper yet.
Science is wonderful. Building on the knowledge developed before us, our tools improve and our ability to explore expands. Piece by piece, photon by photon, galaxy by galaxy, we’re examining this Universe we live in and understanding it better every day.
Image credit: ESO/UltraVISTA team. Acknowledgement: TERAPIX/CNRS/INSU/CASU
Related Posts:
- Another record breaker: ultra-deep image reveals ultra-distant galaxy
- The Helix screams in infrared
- The Milky Way’s buried treasures
- Spectacular VISTA of the Tarantula
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If you started out building a dating site and instead ended up building a video sharing site (YouTube) that handles 4 billion views a day, then it’s just possible you learned something along the way. And indeed, Mike Solomon, one of the original engineers at YouTube, did learn a lot and he has given a talk about it at PyCon: Scalability at YouTube.
This isn’t an architecture driven talk where we are led through a description of how a lot of boxes connect to each other. Mike could give that sort of talk. He has worked on building YouTube’s servlet infrastructure, video indexing feature, video transcoding system, their full text search, a CDN, and much more. But instead, he’s taken a step back, took a long look around at what time has wrought, and shared some deep lessons, obviously hard won from experience.
The key takeaway away of the talk for me was doing a lot with really simple tools. While many teams are moving on to more complex ecosystems, YouTube really does keep it simple. They program primarily in Python, use MySQL as their database, they’ve stuck with Apache, and even new features for such a massive site start as a very simple Python program.
That doesn’t mean YouTube doesn’t do cool stuff, they do, but what makes everything work together is more a philosophy or a way of doing things than technological hocus pocus. What made YouTube into one of the world’s largest websites? Read on and see…
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Survivor. When mice with human tumors received doses of anti-CD47, which sets the immune system against tumor cells, the cancers shrank and disappeared.
Credit: Fotosearch
A single drug can shrink or cure human breast, ovary, colon, bladder, brain, liver, and prostate tumors that have been transplanted into mice, researchers have found. The treatment, an antibody that blocks a “do not eat” signal normally displayed on tumor cells, coaxes the immune system to destroy the cancer cells.
A decade ago, biologist Irving Weissman of the Stanford University School of Medicine in Palo Alto, California, discovered that leukemia cells produce higher levels of a protein called CD47 than do healthy cells. CD47, he and other scientists found, is also displayed on healthy blood cells; it’s a marker that blocks the immune system from destroying them as they circulate. Cancers take advantage of this flag to trick the immune system into ignoring them. In the past few years, Weissman’s lab showed that blocking CD47 with an antibody cured some cases of lymphomas and leukemias in mice by stimulating the immune system to recognize the cancer cells as invaders. Now, he and colleagues have shown that the CD47-blocking antibody may have a far wider impact than just blood cancers.
“What we’ve shown is that CD47 isn’t just important on leukemias and lymphomas,” says Weissman. “It’s on every single human primary tumor that we tested.” Moreover, Weissman’s lab found that cancer cells always had higher levels of CD47 than did healthy cells. How much CD47 a tumor made could predict the survival odds of a patient.
To determine whether blocking CD47 was beneficial, the scientists exposed tumor cells to macrophages, a type of immune cell, and anti-CD47 molecules in petri dishes. Without the drug, the macrophages ignored the cancerous cells. But when the CD47 was present, the macrophages engulfed and destroyed cancer cells from all tumor types.
Next, the team transplanted human tumors into the feet of mice, where tumors can be easily monitored. When they treated the rodents with anti-CD47, the tumors shrank and did not spread to the rest of the body. In mice given human bladder cancer tumors, for example, 10 of 10 untreated mice had cancer that spread to their lymph nodes. Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer. Moreover, the implanted tumor often got smaller after treatment — colon cancers transplanted into the mice shrank to less than one-third of their original size, on average. And in five mice with breast cancer tumors, anti-CD47 eliminated all signs of the cancer cells, and the animals remained cancer-free 4 months after the treatment stopped.
“We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis,” says Weissman.
Although macrophages also attacked blood cells expressing CD47 when mice were given the antibody, the researchers found that the decrease in blood cells was short-lived; the animals turned up production of new blood cells to replace those they lost from the treatment, the team reports online today in the Proceedings of the National Academy of Sciences.
Cancer researcher Tyler Jacks of the Massachusetts Institute of Technology in Cambridge says that although the new study is promising, more research is needed to see whether the results hold true in humans. “The microenvironment of a real tumor is quite a bit more complicated than the microenvironment of a transplanted tumor,” he notes, “and it’s possible that a real tumor has additional immune suppressing effects.”
Another important question, Jacks says, is how CD47 antibodies would complement existing treatments. “In what ways might they work together and in what ways might they be antagonistic?” Using anti-CD47 in addition to chemotherapy, for example, could be counterproductive if the stress from chemotherapy causes normal cells to produce more CD47 than usual.
Weissman’s team has received a $20 million grant from the California Institute for Regenerative Medicine to move the findings from mouse studies to human safety tests. “We have enough data already,” says Weissman, “that I can say I’m confident that this will move to phase I human trials.”
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